An important drawback of this technique, specifically in the study of cancer genomes, stems from the utilization of whole genomic DNA purified from tumor tissue where genomically normal cells are almost always present. aCGH however, is not without limitations 13. The study of copy number alterations using aCGH has led to the identification of recurrent amplifications and deletions across many human cancers 11, 12. tumor and matched normal), DNA with fluorophores, hybridization to arrays containing oligonucleotide probes, and subsequent analysis of fluorometric signal ratios, allows for calling of the copy number profile of discrete genomic intervals. aCGH technology, based on differential labeling of sample and reference (e.g. The most commonly utilized method in interrogating the copy number landscape of genomes has been Array Comparative Genomic Hybridization (aCGH) 10. These investigations have allowed for the identification of disease associated alterations that have subsequently been used to guide therapeutic decisions, for example using amplification of the ERBB2 locus to qualify patients for Herceptin 9. Thousands of tumors, across many cancer types, have been profiled using a variety of copy number detection techniques. In cancer, the commonality of copy number alterations has led to intense investigations of the copy number landscapes of tumors 7, 8. Importantly, copy number variation has been linked with a wide range of deleterious phenotypes and disorders such as obesity 4, psychiatric disorders 5, and cancer 6. Many studies have associated copy number variants with normal phenotypes, such as human olfactory receptors and smell 2 and the amylase gene and diet 3. Please call 87 if you require more information.Copy number variation is an important source of genetic variation in humans and other organisms and is known to influences phenotypic traits 1. The discounted service must be pre-booked by calling 87. Express (2-day) and Priority (5-day) One Time Shredding Service are not eligible for this offer. This offer is subject to availability, is for participating branches in North America only, is non-transferable, has no monetary value and cannot be combined with any other offer. Additional charges may apply if stairs or additional labor required during service. This offer will only be valid until Decemfor services contracted on or before December 30, 2022. This offer entitles new and existing customers up to a 25% discount of Shred-it’s local list price for one-time shredding service, paper or hard drive, with a minimum value of $1,000 plus applicable taxes, or a 10% discount off Shred-it’s local list price for orders with a value of less than $1,000 plus applicable taxes, subject to a minimum visit charge of $252. This can be set up as a standalone service or added as part of a regularly scheduled service. If you have old hard drives, flash drives, or other media, only physical destruction guarantees the information is destroyed. Pair it with regularly scheduled paper shredding service or just call us for a one-time purge and let our secure document destruction service destroy your stored files. If you have storage boxes piling up or filing cabinets full to the brim, take advantage of our one-time paper shredding clear-out service. After destruction, 100% of paper is securely recycled, reducing your carbon footprint. Our professional document shredding services come with a Certificate of Destruction and is NAID AAA certified. Highly recommended for legal, financial, government, education, healthcare, or business services industries we are trained in a wide variety of compliance legislations. Get best-in-class document destruction perfect for every business. secure cross-cut shredding) technology found in most office shredders can lead to documents being easily reconstructed The reliability of employees to follow a secure document management process may be inconsistent.Confidential paper waiting for the office shredder can be stolen or misplaced.The amount of time it takes employees to gather, sort, and shred the documents is often underestimated. Many organizations that shred their private and confidential documents themselves think they are saving time and money, but there are many hidden costs - and risks - to using an office shredder:
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